ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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Challenges in Treating an Elderly Patient with Comorbid Tuberculosis and Nontuberculous Mycobacterial Pulmonary Infection: a Clinical Case

Bibliography link: Degtyareva S. A., Zaitseva A. S., Karpina N. L., Chernousova L. N., Stepanyan I. E., Shmelyov E. I. Challenges in Treating an Elderly Patient with Comorbid Tuberculosis and Nontuberculous Mycobacterial Pulmonary Infection: a Clinical Case. Doctor.Ru. 2017. 10(139): 49–52.
20 October 00:00

Objective of the Paper: To demonstrate challenges in the diagnosis and treatment of an elderly patient with comorbid tuberculosis and nontuberculous mycobacterial (NTM) pulmonary infection, as well as some concomitant diseases.

Key Points: The paper describes the clinical case of an 86-year-old patient with tuberculosis, NTM pulmonary infection, and concomitant diseases, including chronic obstructive pulmonary disease (COPD). In-hospital treatment achieved remission of COPD, but all attempts to treat the NTM pulmonary infection resulted in pronounced cardiotoxic side effects.

Conclusion: This case demonstrates difficulty of diagnosing and treating an elderly patient with comorbid tuberculosis, NTM pulmonary infection, and some concomitant diseases. Antibacterial therapy, administered for continuously active mycobacteriosis with persistent discharge of NTM after tuberculosis had been clinically cured, was discontinued due to life-threatening side effects.

S. A. Degtyareva — Central Tuberculosis Research Institute, Moscow. E-mail: bonita.lana@mail.ru

A. S. Zaitseva — Central Tuberculosis Research Institute, Moscow. E-mail: bonita.lana@mail.ru

N. L. Karpina — Central Tuberculosis Research Institute, Moscow. E-mail: bonita.lana@mail.ru

L. N. Chernousova — Central Tuberculosis Research Institute, Moscow. E-mail: bonita.lana@mail.ru

I. E. Stepanyan — Central Tuberculosis Research Institute, Moscow. E-mail: bonita.lana@mail.ru

E. I. Shmelyov — Central Tuberculosis Research Institute, Moscow. E-mail: eishmelev@mail.ru


Доктор.ру
20 October 00:00
LITERATURE
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  2. Prevos R., Marras T. K. Epidemiologу of human pulmonary infection with nontuberculous mycobacteria. In: Huitt G. A., Daley Ch. L., eds. Nontuberculous mycobacteria. Elsevier; 2015: 13–31.
  3. Daley Ch. L., Griffith D. E. Pulmonary non-tuberculous mycobacterial infections. Int. J. Tuberc. Lung. Dis. 2010; 14(6): 665–71.
  4. Гунтупова Л. Д., Борисов С. Е., Макарова М. В., Хачатурьянц Е. Н. Микобактериозы органов дыхания: эпидемиология, микробиологические и клинические аспекты диагностики. Эпидемиология и инфекционные болезни. 2012; 2: 8–14. [Guntupova L. D., Borisov S. E.,Makarova M. V., Khachatur’yants E. N. Mikobakteriozy organov dykhaniya: epidemiologiya, mikrobiologicheskie i klinicheskie aspekty diagnostiki. Epidemiologiya i infektsionnye bolezni. 2012; 2: 8–14. (in Russian)]
  5. Оттен Т. Ф. Микобактериоз. В кн.: Лабинская А. С., Волгина Е. Г., Ковалева Е. П., ред. Руководство по медицинской микробиологии. Кн. III. Т. 2. Оппортуниститечкие инфекции: клинико-эпидемиологические аспекты. М.: Бином; 2014: 349–65. [Otten T. F. Mikobakterioz. V kn.: Labinskaya A. S., Volgina E. G., Kovaleva E. P., red. Rukovodstvo po meditsinskoi mikrobiologii. Kn. III. T. 2. Opportunistitechkie infektsii: kliniko-epidemiologicheskie aspekty. M.: Binom; 2014: 349–65. (in Russian)]
  6. Griffith D. E., Aksamit T., Brown-Elliott B. A., Catanzaro A., Daley Ch. L., Gordin F. et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am. J. Respir. Crit. Care Med. 2007; 175(4): 367–416.
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