Immunotherapy for Inflammatory Bowel Disease

For citation: Nikonov E.L., Aksyonov V.A., Skvortsova T.A., Zharova M.E. Immunotherapy for Inflammatory Bowel Disease. Doctor.Ru. 2019; 10(165): 31–37. (in Russian) DOI: 10.31550/1727-2378-2019-165-10-31-37
11 september 2019

Objective of the Review: To analyze data in the international literature on immunobiological medications for inflammatory bowel disease (IBD) and the treatment of IBD in pediatric patients.

Key Points: The global prevalence of IBD is about 0.3%, which causes significant economic losses, both direct and indirect. Since the 1990s, the therapeutic paradigm for IBD has changed: traditional groups of medications, which act non-selectively on targets in the immune-inflammation process, have been replaced by highly selective immunobiological medications. This review describes the main groups of immunobiological medications and outlines various treatment strategies for IBD in pediatric patients.

Conclusion: Appropriate and timely treatment of IBD, especially in pediatric practice, has been proven to reduce the risk of complications and improve quality of life.

Contribution: Nikonov, E.L. — coordination, search for references; Aksenov, V.A. — search for references, references systematization; Skvortsova, T.A. — references review, text of the article; Zharova, M.E. — search for references.

Conflict of interes: The authors declare that they do not have any conflict of interests.

E.L. Nikonov — N.I. Pirogov Russian National Research Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Ministry of Health; 1 Ostrovityanov St., Moscow, Russian Federation 117997. eLIBRARY.RU SPIN: 5618-1533. E-mail: drnikonov@mail.ru

V.A. Aksyonov — Russian Society for Evidence-based Medicine (an Interregional Public Organization); 46 Dmitrovskoye Shosse Bldg. 2, Office 17, Moscow, Russian Federation 127238. E-mail: V.Aksenov@ogp.ru

T.A. Skvortsova — Morozov City Pediatric Clinical Hospital (a Government-funded Healthcare Institution) Moscow City Department of Health; 1/9 4th Dobryninsky Pereulok, Moscow, Russian Federation 119049. eLIBRARY.RU SPIN: 6178-3323. E-mail: 79151289538@ya.ru

M.E. Zharova — N.I. Pirogov Russian National Research Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Ministry of Health; 1 Ostrovityanov St., Moscow, Russian Federation 117997. Research Institute for Healthcare Organization and Medical Management (a Government-funded Institution), Moscow City Department of Health; 30 Bolshaya Tatarskaya St., Moscow, Russian Federation 115184. eLIBRARY.RU SPIN: 4882-3634. ORCID: https://orcid.org/0000-0002-8325-5927. E-mail: zharowa.mariya@yandex.ru

11 September 11:08
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