A PEER-REVIEWED JOURNAL OF RESEARCH AND CLINICAL MEDICINEISSN 1727-2378 (Print)         ISSN 2713-2994 (Online)
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‘Correct’ Nimesulide: A Pharmacologist's Opinion

DOI:10.31550/1727-2378-2019-165-10-38-42
For citation: Knorring G.Yu., Vyortkin A.L. ‘Correct’ Nimesulide: A Pharmacologist's Opinion. Doctor.Ru. 2019; 10(165): 38–42. (in Russian) DOI: 10.31550/1727-2378-2019-165-10-38-42
11 September 12:15

Objective of the Review: To discuss the results of pharmacokinetic studies of nimesulide with improved disintegration parameters, which significantly contribute to its therapeutic effect.

Key Points: The advantages of nimesulide include high bioavailability, effective pain relief, and a powerful anti-inflammatory effect. The rapid onset of Nise’s analgesic action is due to a so-called 3D-effect, which is a high rate of tablet disintegration. The rapid and prolonged pain relief provided by nimesulide is explained by a wide range of effects not related to cyclooxygenase-2 inhibition.

Conclusion: These properties of nimesulide make it the analgesic and anti-inflammatory medication of choice in broad clinical practice.

Contribution: Knorring, G.Yu. — thematic publications reviewing, manuscript preparation, review of critically important material; Vyortkin, A.L. — review of critically important material, approval of the manuscript for publication.

Conflict of interes: The authors declare that they do not have any conflict of interests.


G.Yu. Knorring — A.I. Yevdokimov Moscow State University of Medicine and Dentistry (a Federal Government-funded Educational Institution of Higher Education), Russian Ministry of Health; 20 Delegatskaya St., Bldg. 1, Moscow, Russian Federation 127473. eLIBRARY.RU SPIN: 1674-4747. ORCID: https://orcid.org/0000-0003-4391-2889. E-mail: knorring@mail.ru

A.L. Vyortkin — A.I. Yevdokimov Moscow State University of Medicine and Dentistry (a Federal Government-funded Educational Institution of Higher Education), Russian Ministry of Health; 20 Delegatskaya St., Bldg. 1, Moscow, Russian Federation 127473. eLIBRARY.RU SPIN: 9605-9117. ORCID: https://orcid.org/0000-0001-8975-8608. E-mail: kafedrakf@mail.ru



Доктор.ру
11 September 12:15
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